Evaluasi Nevirapine pada Terapi ARV Tahun Pertama dan Kedua Terhadap Fungsi Hati di Puskesmas Kecamatan Cilandak: Studi Kadar SGOT dan SGPT

Burhannudin Burhannudin

doi:10.59946/jfki.2023.221

Evaluasi Nevirapine pada Terapi ARV Tahun Pertama dan Kedua Terhadap Fungsi Hati di Puskesmas Kecamatan Cilandak: Studi Kadar SGOT dan SGPT

Burhannudin Burhannudin Poltekkes Kemenkes Jakarta III

DOI: https://doi.org/10.59946/jfki.2023.221

Kata Kunci: Nevirapine, Terapi Antiretroviral, Fungsi hati, SGOT, SGPT

Abstrak

Terapi Anti-retroviral (ARV) merupakan pengobatan terbaik untuk mencegah dan mengatasi infeksi Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) yang merupakan proses berkepanjangan dan memerlukan pemantauan secara berkala. Penggunaan regimen Nevirapine dianjurkan karena efikasinya yang bagus namun diduga dapat menyebabkan hepatotoksisitas pada hati. Gangguan hati dapat diamati dengan pengukuran kadar enzim SGOT dan SGPT dalam tubuh pasien HIV/AIDS pasca terapi ARV. Penelitian ini bertujuan untuk mengamati penggunaan regimen Nevirapine pada tahun pertama dan kedua pasca terapi ARV terhadap fungsi hati dilihat dari kadar SGOT dan SGPT. Penelitian ini merupakan penelitian observasional dengan pendekatan studi potong lintang menggunakan data sekunder pasien HIV/AIDS pengguna regimen Nevirapine di Puskesmas Kecamatan Cilandak pada bulan Januari 2019 – Desember 2022 sejumlah 113 responden dengan 40 pasien terapi 1 tahun dan 73 pasien terapi 2 tahun yang memeriksakan normal atau tidaknya kadar SGOT dan SGPT-nya pasca terapi. Terapi Nevirapine tahun pertama menunjukkan persentase kadar SGOT dan SGPT yang abnormal masih menyerupai sebelum menjalani terapi (2,50%), namun persentasenya meningkat pada tahun kedua (30,20% SGOT dan 60,28% SGPT). Uji spearman’s rank digunakan untuk mengetahui korelasi peningkatan kadar SGOT dan SGPT sepanjang waktu terapi dan menujukkan hasil SGOT memiliki koefisien korelasi sebesar 0,33 (p<0,05) dan SGPT sebesar 0,56 (p<0,05) dari tahun pertama dan kedua. Peningkatan kadar SGOT dan SGPT dapat mengindikasikan adanya permasalahan pada fungi hati, namun perlu pendekatan lebih mendalam untuk mendiagnosis kerusakan fungsi hati. Penggunaan Nevirapine perlu dipantau terus menerus untuk memantau perkembangan fungsi hati pasien terapi ARV regimen Nevirapine.

Referensi

Ajmala, I. E. dan Wulandari, L. 2015. Terapi ARV pada Penderita Ko-Infeksi TB-HIV. Jurnal Respirasi 1(1): 22-28.
Amelia, M., Hadisaputro, S., Laksono, B., Anies dan Sofro, M. A. U. 2016. Faktor risiko yang berpengaruh terhadap kejadian HIV/AIDS pada laki-laki umur 25-44 tahun di kota Dili, Timor Leste. Jurnal Epidemiologi Kesehatan Komunitas 1(1): 39-47.
Andayani, P. L., Santoso, K., Kusumorini, N., Satyaningtijas, A. S. dan Supriyani, A. 2016. Bioma 12(1): 60-68.
Augustha, A. B., Wahab, Z. dan Ratnaningrum, K. 2018. Perubahan kadar hemoglobin dan nilai enzim aminotransferase pada terapi antiretriviral lini pertama. Ibnu Sina Biomedika 2(1): 1-6.
Ditjen P2P. 2021. Laporan perkembangan HIV AIDS dan penyakit infeksi menular seksual (PIMS) triwulan I tahun 2021. https://siha.kemkes.go.id/portal/files_upload/Laporan_TW_I_2021_FINAL.pdf. Diakses tanggal 23 Maret 2023.
Eckhardt, B. J. dan Gulick, R. M. 2017. Drugs for HIV infection. Infectious disease pp. 1300-1301.
Fan-Havard, P., Liu, Z., Chou, M., Ling, Y., Barrail-Tran, A., Haas, D. W. dan Taburet, A. 2013. Pharmacokinetics of Phase I Nevirapine Metabolites Following a Single Dose and at Steady State. Antimicrob Agents Chemother 57(5): 2154-2160.
Firdaus, J., Febianti, Z., Hidayat, M. R. F. dan Sakinah, E. N. 2022. Efek Neem Gum (Azadiracthta indica) terhadap kadar SGOT SGPT tikus Wistar yang diinduksi Diazinon. Journal of Nutrition College 11(3): 258-263.
Giacomelli, A., Riva, A., Falvella, F. S., Oreni, M. L., Cattaneo, D., Cheli, S., Renisi, G., Di Cristo, V., Lupo, A., Clementi, E., Rusconi, S., Galli, M. dan Ridolfo, A. L. 2018. Clinical and genetic factors associated with increased risk of severe liver toxicity in a monocentric cohort of HIV positive patients reciving nevirapine-based antiretroviral therapy. BMC Infectious Disease
Hidayat, R., Amir, H., Agus, A. I. dan Hisyam, M. 2023. Pengaruh lama pemberian obat antoretroviral terhadap sel CD4 pada penderita HIV/AIDS di Makassar Indonesia. An Idea Nursing Journal 2(1): 24-30.
Kementerian Kesehatan RI. 2019. Laporan perkembangan HIV AIDS dan penyakit infeksi menular seksual (PMS) triwulan II tahun 2019. Direktorat Pencegahan dan Pengendalian Penyakit, Jakarta.
Kurniawati, I., Nurmasitoh, T. dan Yahya, T. N. 2015. Effect of giving ethanol multistep doses to level SGPT and SGOT in wistar rat (Rattus norvegicus). Jurnal Kedokteran dan Kesehatan Indonesia 7(1): 30-35.
Meriyani, H., Udayani, N. N. W. dan Adrianta, K. A. Evaluasi fungsi hati pada pasien HIV/AIDS dengan terapi ARV di RSUD Mangusada. Jurnal Ilmiah Medicamento 4(2): 113-117.
Nursalam, Kurniawati, N. D., Misutamo, Solikhah, F. K. 2018. Asuhan keperawatan pada pasien terinfeksi HIV/AIDS ed. 2. Salemba Medika, Jakarta.
Oladipo, E. K., Afolabi, A. Y., Omomowo, I. O., Oloke, J. K. dan Awoyelu, E. H. 2016. Histological and biochemical markers of the liver of male wistar rats on oral administration of nevirapine suspension. African Journal of Clinical and Experimental Microbiology 17(1): 53-61.
Panel on Antiretroviral Guidelines for Adults and Adolescents. 2023. Guidelines for the use of antiretroviral agents in adults and adolescents with HIV. https://clinicalinfo.hiv.gov.en/guidelines/adult-and-adolescent-arv. Diakses tanggal 23 Maret 2023.
Pathania, S., Kaur, M., Kumar, S., Sashindran, V. K. dan Puri, P. 2017. A cross-sectional study of liver function tests in HIV-infected persons on western India. Med J Armed Forces India 73(1): 23-28.
Rahakbauw, N. 2016. Dukungan keluarga terhadap kelangsungan hidup ODHA (orang dengan HIV/AIDS). Insani 3(2): 64-82.
Rehman, N. dan Nguyen, H. Nevirapine dalam StatPearls (internet). https://www.ncbi.nlm.nih.gov/books/NBK554477/. Diakses tanggal 23 Maret 2023.
Rohmatullailah, D. dan Fikriyah, D. 2021. Faktor risiko kejadian HIV pada kelompok usia produktif di Indonesia. Bikfokes 2(1): 45-59.
Sarifatun. 2022. Literature review: efektivitas pemberian terapi antiretroviral dengan pemeriksaan cluster of differentiation 4 (CD4) pada pasien HIV. Universitas ‘Aisyiyah Yogyakarta, Yogyakarta.
Shanyengana, L. P., Mukesi, M., van der Colf, B. E. dan Moyo, S. R. 2016. Serum alanine aminotransferase elevations in HIV positive patients on antiretroviral therapy in Namibia. World Journal of AIDS 6(3): 101-110.
Sinaga, H. dan Hasim, M. H. 2019. Pemeriksaan fungsi hati pada penderita HIV dengan terapi ARV ≥ 6 bulan di Rumah Sakit Marthen Indey (RSMI) Jayapura. Jurnal Riset Kesehatan 8(1): 28-34.
Yunior, N. dan Wardani, I. K. F. 2018. Faktor-faktor yang berhubungan dengan kejadian HIV/AIDS di RSUD Kabupaten Bekasi tahun 2018. Stikes Medika Cikarang, Bekasi.

PDF (English)

Diterbitkan

2023-10-31

##submission.howToCite##

Burhannudin, B. (2023). Evaluasi Nevirapine pada Terapi ARV Tahun Pertama dan Kedua Terhadap Fungsi Hati di Puskesmas Kecamatan Cilandak: Studi Kadar SGOT dan SGPT. Jurnal Fisioterapi Dan Kesehatan Indonesia, 3(2), 52-60. https://doi.org/10.59946/jfki.2023.221

##submission.howToCite.downloadCitation##

Terbitan

Vol 3 No 2 (2023): Jurnal Fisioterapi dan Kesehatan Indonesia

Bagian

Articles

##submission.copyrightStatement##

##submission.license.cc.by-nc-sa4.footer##

Things to do before submission

Ethics in publishing

Please see our information pages on Publication Ethics and Malpractice Statement for journal publication.

Authorship

All authors should have made substantial contributions to all of the following:

(1) the conception and design of the study, or acquisition of data, or analysis and interpretation of data

(2) drafting the article or revising it critically for important intellectual content

Changes to authorship

Authors are expected to consider carefully the list and order of authors before submitting their manuscript and provide the definitive list of authors at the time of the original submission. Any addition, deletion or rearrangement of author names in the authorship list should be made only before the manuscript has been accepted and only if approved by the journal Editor.

To request such a change, the Editor must receive the following from the corresponding author: (a) the reason for the change in author list and (b) written confirmation (e-mail, letter) from all authors that they agree with the addition, removal or rearrangement. In the case of addition or removal of authors, this includes confirmation from the author being added or removed.

Only in exceptional circumstances will the Editor consider the addition, deletion or rearrangement of authors after the manuscript has been accepted. While the Editor considers the request, publication of the manuscript will be suspended. If the manuscript has already been published in an online issue, any requests approved by the Editor will result in a corrigendum.

Copyright

Upon acceptance of an article, authors will be asked to complete a ‘Copyright Transfer Agreement’ (see more information). Permitted third party reuse of open access articles is determined by open access license CC BY NC SA.

Author rights

As an author, you (or your employer or institution) have certain rights to reuse your work. More information.

Open access

This is an open access journal: all articles will be immediately and permanently free for everyone to read and download (see more information). Permitted third party (re)use is defined by Creative Commons Attribution (CC BY NC SA). More information.

Language

Please write your text in good English (American or British usage is accepted, but not a mixture of these). Every article accepted by MEV Journal shall be an object to Grammarly® writing-enhancement program conducted by MEV Journal Editorial Board.

Referees

Please submit, with the manuscript, the names, institution, addresses, and e-mail addresses of two potential referees. Suggested reviewers should have similar expertise with the topic of the paper and should not have any conflict of interest with the submitted paper or author/coauthor of the paper. Suggested reviewers should also not listed as Editorial Board of MEV Journal. Note that the editors retain the sole right to decide whether or not the suggested reviewers are assigned.

Preparing the manuscript

Formatting requirements

Please use the author submission template available online at MEV Journal website. To use the template, kindly ‘Save As’ the MS Word file to your document, then copy and paste your document. To copy and paste the text into the template, please use ‘Special Paste’ and choose ‘Unformatted Text’. Papers not prepared in accordance with author guidelines and manuscripts with number of mistakes will have to be pre-rejected by Editor.

Download the ‘Author Submission Template’ DOCX

http://www.mevjournal.com/mevfiles/MEV_author_submission_template_17.1.docx

If your article includes any Videos and/or other Supplementary material, this should be included in your supplementary file at initial submission for peer review purposes.

Word Processing Software

The manuscript should contain at least 2.000 words and should not exceed 25 pages including embedded figures and tables, contain no appendix, and the file should be in Microsoft Office (.doc/.docx) or Open Office (.odt) format. The paper should be prepared in A4 paper (210 mm x 297 mm) using 25 mm for left margin and 2 mm for the top, bottom, and right margin. No need to alter page number in this template as the page number will be reordered at preprinting process. The whole manuscript body should be in one column, using font type Times New Roman (TNR), font size 12, first line indent 5 mm, and 1.5 line spacing.

Please make sure that you use as much as possible normal fonts in your documents. Special fonts, such as fonts used in the Far East (Japanese, Chinese, Korean, etc.) may cause problems during processing. To avoid unnecessary errors, you are strongly advised to use the ‘spellchecker’ function of MS Word.

Section Headings

Divide your article into clearly defined and numbered sections. The abstract is not included in section numbering. Use this numbering also for internal cross-referencing: do not just refer to 'the text'. Any subsection may be given a brief heading. Each heading should appear on its own separate line.

Heading should be made in four levels. Level five cannot be accepted.

Heading Level 1; Heading 1 should be written in title case, left aligned, bold, 14 TNR, and Roman numbered followed by a dot.
Heading Level 2; Heading 2 should be written title case, left aligned, bold, 12 TNR, Capital Arabic numbered followed by a dot.
Heading Level 3; Heading 3 should be written title case, left aligned, italic, 12 TNR, numbered by Arabic number followed by closed bracket
Heading level 4; Heading 4 is not recommended, however, it could still be accepted with the format of sentence case, left indent 5 mm, hanging indent 5 mm, italic, 12 TNR, numbered by small cap followed by a closed bracket.
Heading Level 5; Heading Level 5 cannot be accepted in the manuscript.

Article structure

The manuscript should begin with title, abstract, and keyword(s) followed by the main text. The main text should consist of at least IMRaD structure, except for the review article: Introduction, Method/Material, Result and Discussion, and Conclusion; followed by acknowledgement and References.

Introduction

State the objectives of the work and provide an adequate background, state of the art, and should be avoiding a detailed literature survey or a summary of the results. Explain how you addressed the problem and clearly state the aims of your study.

Materials and methods

Provide sufficient details to allow the work to be reproduced by an independent researcher. Methods that are already published should be summarized and indicated by a reference. If quoting directly from a previously published method, use quotation marks and also cite the source. Any modifications to existing methods should also be described.

A Theory section (if necessarily added) should extend, not repeat, the background to the article already dealt with in the Introduction and lays the foundation for further work. A Calculation section represents a practical development from a theoretical basis.

Results and discussions

Results should be clear and concise. Discussion should explore the significance of the results of the work, not repeat them. Avoid extensive citations and discussion of published literature.

The following components should be covered in the discussion section: How do your results relate to the original question or objectives outlined in the Introduction section (what)? Do you provide interpretation scientifically for each of your results or findings presented (why)? Are your results consistent with what other investigators have reported (what else)? Or are there any differences?

Conclusions

The main conclusions of the study may be presented in a short Conclusions section, which may stand alone or form a subsection of a Discussion or Results and Discussion section. The conclusion section should lead the reader to the important matter of the paper. Suggestion or recommendation related to further research can also be added but not to confuse the research with an uncompleted work.

Acknowledgements

Collate acknowledgements in a separate section at the end of the article before the references and do not, therefore, include them on the title page, as a footnote to the title or otherwise. List here those individuals who provided help during the research (e.g., providing language help, writing assistance or proof reading the article, etc.).

Appendices

It is not recommended to use appendices in MEV Journal submission.

Essential title page information

Title

The title of the manuscript should be concise and informative, less than 15 words, title case, centered, bold. Titles are often used in information-retrieval systems. The title should be accurate, unambiguous, specific, and completely identify the main issue of the paper. Avoid abbreviations and formulae where possible.

Author names and affiliations

Author names should not contain academic title, official rank, or professional position. Please clearly indicate the given name(s) and last/family name(s) -full name if possible- of each author and check that all names are accurately spelled. Present the authors' affiliation addresses (where the actual work was done) below the names. Write clear affiliation of all Authors. Affiliation includes name of department/unit, (faculty), the name of university/institution, complete postal address, and country. All contributing author should be shown in contribution order.

Corresponding author

Clearly indicate the corresponding author clearly for handling all stages of pre-publication, refereeing, and post-publication. This responsibility includes answering any future queries about Methodology and Materials. Ensure that the e-mail address is given and that contact details are kept up to date by the corresponding author.

Present/permanent address

If an author has moved since the work described in the article was done, or was visiting at the time, a 'Present address' (or 'Permanent address') may be indicated as a footnote to that author's name. The address at which the author actually did the work must be retained as the main, affiliation address. Superscript Arabic numerals are used for such footnotes.

Abstract and keywords

Abstract

Abstract should be concise and factual, contains neither pictures nor tables, and should not exceed 250 words. The abstract should state briefly the purpose of the research, research materials and methods, the principal results, and major conclusions. An abstract is often presented separately from the article, so it must be able to stand alone. For this reason, References should be avoided, but if essential, then cite the author(s) and year(s). Also, non-standard or uncommon abbreviations should be avoided, but if essential they must be defined at their first mention in the abstract itself.

Graphical abstract

A graphical abstract is optional. Its use is encouraged as it draws more attention to the online article. The graphical abstract should summarize the contents of the article in a concise, pictorial form designed to capture the attention of a wide readership. Graphical abstracts should be submitted as a supplementary file in the online submission system. Image size: Please provide an image with a minimum of 531 × 1328 pixels (h × w) or proportionally more. The image should be readable at a size of 5 × 13 cm using a regular screen resolution of 96 dpi. Preferred file types: TIFF, EPS, PDF or MS Office files. You can view Example Graphical Abstracts on our information site.

Keywords

The keywords should be avoiding general and plural terms and multiple concepts. Be sparing with abbreviations: only abbreviations firmly established in the field may be eligible. These keywords will be used for indexing purposes.

Instruments

Abbreviations, Acronyms, and Units

Define abbreviations and acronyms at the first time they are used in the text, even after they have been defined in the abstract. Abbreviations such as IEEE, SI, MKS, CGS, sc, dc, and rms do not have to be defined. Do not use abbreviations in the title or heads unless they are unavoidable.

Use either SI (MKS) or CGS as primary units. (SI units are encouraged.) English units may be used as secondary units (in parentheses). An exception would be the use of English units as identifiers in trade, such as “3.5-inch disk drive.”Avoid combining SI and CGS units, such as current in amperes and magnetic field in oersteds. This often leads to confusion because equations do not balance dimensionally. If you must use mixed units, clearly state the units for each quantity that you use in an equation.

Do not mix complete spellings and abbreviations of units: “Wb/m²” or “webers per square meter,” not “webers/m².” Spell units when they appear in text: “...a few henries,” not “...a few H.” Use a zero before decimal points: “0.25,” not “.25.” Use “cm3,” not “cc”.

Math formulae

Mathematical equation should be clearly written, numbered orderly, and should be an editable text prepared using MS Equation Editor (not in image format) and should also be separated from the surrounding text. Be sure that the symbols in your equation have been defined before or immediately following the equation. Use “(1),” not “Eq. (1)” or “equation (1),” except at the beginning of a sentence: “Equation (1) is ...”. Italicize Roman symbols for quantities and variables, but not Greek symbols. Use a long dash rather than a hyphen for a minus sign.

Header-footer and hyperlink

Header and footer including page number must not be used. All hypertext links and section bookmarks will be removed from papers. If you need to refer to an Internet email address or URL in your paper, you must type out the address or URL fully in Regular font.

Footnotes

Footnotes should be avoided if possible. Necessary footnotes should be denoted in the text by consecutive superscript letters. The footnotes should be typed at the foot of the page in which they are mentioned, and separated from the main text by a short line extending at the foot of the column.

Figure and table

Figure should be in grayscale, and if it made in color, it should be readable (if it later printed in grayscale). A caption should be sequentially numbered with Arabic numerals and comprise a brief title (not on the figure itself) and a description of the illustration. Keep text in the illustrations themselves to a minimum but explain all symbols and abbreviations used. The lettering on the artwork should be clearly readable and in a proportional measure and should have a finished, printed size of 8 pt for normal text and no smaller than 6 pt for subscript and superscript characters. Use words rather than symbols or abbreviations when writing Figure axis labels to avoid confusing the reader. As an example, write the quantity “Magnetization,” or “Magnetization, M,” not just “M.” If including units in the label, present them within parentheses. Do not label axes only with units. In the example, write “Magnetization (A/m)” or “Magnetization (A ( m(1),” not just “A/m.” Do not label axes with a ratio of quantities and units. For example, write “Temperature (K),” not “Temperature/K.”

Figures should have a brief description in the main body of the manuscript. Insert figures and tables after they are cited in the text. For layouting purpose, please provide high resolution figure (≥300dpi) in .tif/.jpg/.jpeg. Low-quality scans are not acceptable. Figures and tables should be embedded and not supplied separately. Moreover, kindly avoid mentioning the position of figure/table e.g. “figure below” or “table as follow” because the position will be rearranged in layouting process. DO NOT put boxes around your figures to enclose them.

We suggest that you use a text box to insert a graphic (which is ideally at least 300 dpi resolution TIFF or EPS file with all fonts embedded) because this method is somewhat more stable than directly inserting a picture. To have non-visible rules on your frame, use the MSWord “Format” pull-down menu, select Text Box > Colors and Lines to choose No Fill and No Line.

Image manipulation

Whilst it is accepted that authors sometimes need to manipulate images for clarity, manipulation for purposes of deception or fraud will be seen as scientific ethical abuse and will be dealt with accordingly. For graphical images, this journal is applying the following policy: no specific feature within an image may be enhanced, obscured, moved, removed, or introduced. Adjustments of brightness, contrast, or color balance are acceptable if and as long as they do not obscure or eliminate any information present in the original.

Electronic artwork

General points:

Make sure you use uniform lettering and sizing of your original artwork.
Preferred fonts: Arial (or Helvetica), Times New Roman (or Times), Symbol, Courier.
Number the illustrations according to their sequence in the text.
Use a logical naming convention for your artwork files.

Formats

Regardless of the application used, when your electronic artwork is finalized, please 'save as' or convert the images to one of the following formats (note the resolution requirements for line drawings, halftones, and line/halftone combinations given below):

EPS (or PDF): Vector drawings. Embed the font or save the text as 'graphics'.
TIFF (or JPG): Color or grayscale photographs (halftones): always use a minimum of 300 dpi.
TIFF (or JPG): Bitmapped line drawings: use a minimum of 1000 dpi.
TIFF (or JPG): Combinations bitmapped line/half-tone (color or grayscale): a minimum of 500 dpi is required.

Please do not:

Supply files that are optimized for screen use (e.g., GIF, BMP, PICT, WPG); the resolution is too low.
Supply files that are too low in resolution.
Submit graphics that are disproportionately large for the content.

Figure captions

Ensure that each illustration has a caption. A caption should comprise a brief title (not on the figure itself) and a description of the illustration. Keep text in the illustrations themselves to a minimum but explain all symbols and abbreviations used. figure caption of a single line must be centered whereas multi-line captions must be justified

Tables

Please submit tables as editable text and not as images. Number tables consecutively with Arabic numerals in accordance with their appearance in the text. Place footnotes below the table body and indicate them with superscript lowercase letters. Be sparing in the use of tables and ensure that the data presented in them do not duplicate results described elsewhere in the article. Please avoid using vertical rules and shading in table cells.

Construction of references

References are recommended using IEEE referencing style. Please ensure that every reference cited in the text is also present in the reference list (and vice versa). References should be listed at the end of the paper and numbered in the order of their appearance in the text. The template will number citations consecutively within brackets [1]. The sentence punctuation follows the bracket [2]. Refer simply to the reference number, as in [3]—do not use “Ref. [3]” or “reference [3]” except at the beginning of a sentence: “Reference [3] was the first ...”

Unpublished results and personal communications are not recommended in the reference list but may be mentioned in the text. If these references are included in the reference list, they should follow the standard reference style of the journal and should include a substitution of the publication date with either 'Unpublished results' or 'Personal communication'. Citation of a reference as 'in press' implies that the item has been accepted for publication. Wikipedia, personal blog, or non-scientific website is not allowed to be taken into account. Primary references should be at least 80% from at least fifteen references. References should be taken from the late ten years.

Avoid bulk references such as [1–9]. Avoid excessive self-citations (no more than 20%). If possible, article’s DOI should be given for each reference list. Note that missing data will be highlighted at proof stage for the author to correct.

Reference formatting

There are two types of references, i.e., electronics sources and nonelectronics sources. Sample of correct formats for various types of references are as follows

Book: Author, Title. edition, editor , City, State or Country: Publisher, year, Pages.
Part of book: Author, “Title”, in Book, edition, editor, City, State or Country: Publisher, year, Pages.
Periodical: Author, “Title”, Journal, volume (issue), pages, month, year.
Proceeding: Author, “Title”, in Proceeding, year, pages.
Unpublished paper: Author, “Title”, presented at Conference/ event title, City, State or Country, year.
Paten/Standart: Author, “Title”, patent number, month day, year.
Technical report: Author, “Title”, Company, City, State or Country, Tech. Rep. Number, month, year.

Three pieces of information are required to complete each reference from electronics sources: 1) protocol or service; 2) location where the item is to be found; and 3) item to be retrieved. Sample of correct formats for electronics source references are as follows:

Book: Author. (year, month day). Title. (edition) [Type of medium]. volume (issue). Available: site/path/file.
Periodical: Author. (year, month). Title. Journal. [Type of medium]. volume (issue), pages. Available: site/path/file.
Papers presented at conferences: Author. (year, month). Title. Presented at Conference title. [Type of Medium]. Available: site/path/file.
Reports and handbooks: Author. (year, month). Title. Company. City, State or Country. [Type of Medium]. Available: site/path/file.

Reference management software

Every article submitted to MEV Journal shall use reference management software that supports Citation Style Language styles, such as Mendeley and Zotero, as well as EndNote®.

Peer review

MEV uses an online submission and review system. The submission and peer review of every article must be managed using this system and based on following Peer Review Policy.

MEV Editorial Board is responsible for the selection of papers and selection of reviewers.
Articles must typically be reviewed by at least two independent reviewers.
Reviewers are unaware of the identity of the authors, and authors are also unaware of the identity of reviewers (double blind review method)
Reviewing process will consider novelty, objectivity, method, scientific impact, conclusion, and references.
Editor is responsible for the final decision regarding the submission based on reviewer’s recommendation. The Editor's decision is final.
MEV Editorial Board shall protect the confidentiality of all material submitted to the journal and all communications with reviewers.

Complete Peer Review Policy can be found on Peer Review Policy page More information.

After acceptance

Online copyediting

Corresponding authors will receive an e-mail with a link to our online copyediting system, allowing annotation and correction of proofs online. The environment is similar to MS Word: in addition to editing text, you can also comment on figures/tables and answer questions from the Copy Editor. Web-based proofing provides a faster and less error-prone process by allowing you to directly type your corrections, eliminating the potential introduction of errors.

Please use this copyediting stage only for checking the typesetting, editing, completeness, and correctness of the text, tables and figures. Significant changes to the article as accepted for publication will only be considered at this stage with permission from the Editor.

It is important to ensure that all corrections are sent back to us in one communication. Please check carefully before replying, as the inclusion of any subsequent corrections cannot be guaranteed.

After online publication, further changes can only be made in the form of an Erratum, which will be hyperlinked to the article.

Copyright transfer

Authors will be asked to transfer copyright of the article to the Publisher (or grant the Publisher exclusive publication and dissemination rights). This will ensure the widest possible protection and dissemination of information under CC License CC BY-NC-SA.

Offprints

The corresponding author will be notified and receive a link to the published version of the open access article on MEV Journal archive page. This link is in the form of an article DOI link which can be shared via email and social networks. The printed version can be ordered via MEV Printed Version Order Form which is available on MEV official webpage.

Author inquiries

For inquiries relating to MEV Journal, please visit our secretariat at secretariat@mevjournal.com. You can track accepted articles at http://www.mevjournal.com. E-mail alerts and notification will inform you of when an article's status has changed. Also accessible from here is information on copyright, frequently asked questions and more. Contact details for questions arising after acceptance of an article, especially those relating to proofs, will be provided by the publisher.

Download the ‘Author Information Pack’

Download the ‘Author Submission Template’ | for author

Download the ‘Camera Ready Template’ | for layouter

Submission Preparation Checklist

As part of the submission process, authors are required to check off their submission's compliance with all of the following items, and submissions may be returned to authors that do not adhere to these guidelines.

I hereby declare that this submission is my own work.
I hereby stated that this manusrcipt have no plagiarism matter.
I declare the submission has no potential conflict of interest.
I hereby stated that this manusrcipt have never been previously published in any other scientific publication and not being under reviewing process of any other scientific publication.
The submitted manuscript contains no least than 2.000 words and not exceed 25 pages A4 including figures and tables, without any appendixes.
The submitted manuscript has been written using Open Office Text Document (.odt) or Microsoft Word (.doc/.docx).
Title already brief and concise, written in English, and less than 15 words.
Abstract already brief and concise and not exceed 150 words in English.
Keywords are written in English, between three to five phrase.
The manuscript structure already consist: Introduction, Method/Material, Result and Discussion, Conclusion, Acknowledgement, and References.
References are written according the writing style of MEV. The primary references are no less than 80% from at least fifteen sources and had been taken from the late ten year publications.
The instructions in Ensuring a Blind Review have been followed to the submitted manuscript.
(At least) two scientific referees have been suggested in "Comments for the Editor" textbox in the bottom of this page.

Copyright Notice

Retained Rights/Terms and Conditions of Publication

1. As an author you (or your employer or institution) may do the following:

make copies (print or electronic) of the article for your own personal use, including for your own classroom teaching use;
make copies and distribute such copies (including through e-mail) of the article to research colleagues, for the personal use by such colleagues (but not commercially or systematically, e.g. via an e-mail list or list server);
present the article at a meeting or conference and to distribute copies of the article to the delegates attending such meeting;
for your employer, if the article is a ‘work for hire’, made within the scope of your employment, your employer may use all or part of the information in the article for other intra-company use (e.g. training);
retain patent and trademark rights and rights to any process, procedure, or article of manufacture described in the article;
include the article in full or in part in a thesis or dissertation (provided that this is not to be published commercially);
use the article or any part thereof in a printed compilation of your works, such as collected writings or lecture notes (subsequent to publication of the article in the journal); and prepare other derivative works, to extend the article into book-length form, or to otherwise re-use portions or excerpts in other works, with full acknowledgement of its original publication in the journal;
may reproduce or authorize others to reproduce the article, material extracted from the article, or derivative works for the author’s personal use or for company use, provided that the source and the copyright notice are indicated, the copies are not used in any way that implies RCEPM-LIPI endorsement of a product or service of any employer, and the copies themselves are not offered for sale.

All copies, print or electronic, or other use of the paper or article must include the appropriate bibliographic citation for the article’s publication in the journal.

2. Requests from third parties

Although authors are permitted to re-use all or portions of the article in other works, this does not include granting third-party requests for reprinting, republishing, or other types of re-use. Requests for all uses not included above, including the authorization of third parties to reproduce or otherwise use all or part of the article (including figures and tables), should be referred to RCEPM-LIPI by going to our website athttp://telimek.lipi.go.id.

3. Author Online Use

Personal Servers. Authors and/or their employers shall have the right to post the accepted version of articles pre-print version of the article, or revised personal version of the final text of the article (to reflect changes made in the peer review and editing process) on their own personal servers or the servers of their institutions or employers without permission from RCEPM-LIPI, provided that the posted version includes a prominently displayed RCEPM-LIPI copyright notice and, when published, a full citation to the original publication, including a link to the article abstract in the journal homepage. Authors shall not post the final, published versions of their papers;
Classroom or Internal Training Use. An author is expressly permitted to post any portion of the accepted version of his/her own articles on the author’s personal web site or the servers of the author’s institution or company in connection with the author’s teaching, training, or work responsibilities, provided that the appropriate copyright, credit, and reuse notices appear prominently with the posted material. Examples of permitted uses are lecture materials, course packs, e-reserves, conference presentations, or in-house training courses;
Electronic Preprints. Before submitting an article to an MEV Journal, authors frequently post their manuscripts to their own web site, their employer’s site, or to another server that invites constructive comment from colleagues. Upon submission of an article to MEV Journal, an author is required to transfer copyright in the article to RCEPM-LIPI, and the author must update any previously posted version of the article with a prominently displayed RCEPM-LIPI copyright notice. Upon publication of an article by the RCEPM-LIPI, the author must replace any previously posted electronic versions of the article with either (1) the full citation to the work with a Digital Object Identifier (DOI) or link to the article abstract in MEV journal homepage, or (2) the accepted version only (not the final, published version), including the RCEPM-LIPI copyright notice and full citation, with a link to the final, published article in journal homepage.

4. Articles in Press (AiP) service

RCEPM-LIPI may choose to publish an abstract or portions of the paper before we publish it in the journal. Please contact our Production department immediately if you do not want us to make any such prior publication for any reason, including disclosure of a patentable invention.

5. Author/Employer Rights

If you are employed and prepared the article on a subject within the scope of your employment, the copyright in the article belongs to your employer as a work-for-hire. In that case, RCEPM-LIPI assumes that when you sign this Form, you are authorized to do so by your employer and that your employer has consented to the transfer of copyright, to the representation and warranty of publication rights, and to all other terms and conditions of this Form. If such authorization and consent has not been given to you, an authorized representative of your employer should sign this Form as the Author.

6. RCEPM-LIPI Copyright Ownership

It is the formal policy of RCEPM-LIPI to own the copyrights to all copyrightable material in its technical publications and to the individual contributions contained therein, in order to protect the interests of the RCEPM-LIPI, its authors and their employers, and, at the same time, to facilitate the appropriate re-use of this material by others. RCEPM-LIPI distributes its technical publications throughout the world and does so by various means such as hard copy, microfiche, microfilm, and electronic media. It also abstracts and may translate its publications, and articles contained therein, for inclusion in various compendiums, collective works, databases and similar publications

Every accepted manuscript should be accompanied by "Copyright Transfer Agreement" prior to the article publication.